The H3Africa Biorepository Program manages Biospecimen collections from the Human Heredity and Health in Africa (H3Africa) Consortium researchers as well as Biospecimen from other researchers. H3Africa studies are currently collecting DNA and other Biospecimens from participants in 22 African countries to assess genomic and environmental influences on communicable and non-communicable diseases. Whereas Biospecimen collection is done by H3Africa Consortium researchers, quality control and assurance for collection and processing is key to ensure long term future usability. The H3africa Biorepositories have designed tools to ensure quality along the Biospecimen chain from collection to storage and distribution, these include a web-based SPREC, SOPs and training to researchers to ensure quality Biospecimen.